Stratum corneum
G_STRATUM_CORNEUMWhat does this word mean?
The outermost layer of the skin, composed of corneocytes and lipids, and the main physical barrier to penetration.
Expanded note
Bos and Meinardi wrote that larger molecules cannot pass the corneal layer, referring to the stratum corneum, which is where the 500 Da rule takes effect. The site uses it as the visual anchor for the molecular-scale page.
Not a generic example.
PDRN is a polyanionic hydrophilic molecule, so bypass diffusion through stratum corneum lipid channels is also extremely limited.
Related terms
Where this term appears
Educational reference only. This site does not provide medical advice, treatment courses, injection counts, clinic recommendations or price recommendations.
PDRN is not approved by the FDA for injection or any therapeutic use. Topical and injectable PDRN are parallel facts under different regulatory pathways and must not be directly equated.
PN is not PDRN. Evidence grades are labelled on every factual element; in vitro and animal research is never described as clinical efficacy.